ODYSSEY-OUTCOMES - Principal Investigator at SUMMA – Investigating clinical
outcomes in patients with ACS whose lipid levels are not at goal with maximal statin therapy. Comparint the addition of placebo to PCSK-9. On-going
RETRO-HF - Principal Investigator at SUMMA – Coronary sinus injection of SDF-1 encoding Plasmid to enhance Stem Cell homing in patients with ischemic cardiomyopathy. On-going
STOP-HF - Principal Investigator at SUMMA – Intramyocardial injection of SDF-1 encoding Plasmid to enhance Stem Cell homing in patients with ischemic cardiomyopathy. Enrollment complete
IMPROVE-IT – Principal Investigator at SUMMA – Studying the clinical outcomes of simvastatin vs simvastatin/ezetimibe Follow-up phase
CANTOS – Principal Investigator at SUMMA – Studying the clinical outcomes of a new anti-inflammatory monoclonal antibody on patients with prior MI and elevated hsCRP. Enrollment complete
EXAMINE (Takeda) – Principal Investigator at SUMMA – Studying the clinical effect of Alogliptin in patients with ACS and DM Type II. Enrollment complete
PRE-DETERMINE – Principal Investigator at SUMMA – NIH Trial. Following serum markers in patients with prior MI to determine predictablility of event recurrence. Enrollment complete
ANALYZE-ST – Principal Investigator at SUMMA – Studying the safety and effectiveness of the ST Monitoring Feature in the Fortify ST ICD system (or other ICD systems with the ST Monitoring Feature). On-going
PEGASUS – Principal Investigator at SUMMA- Studying the clinical effect of ticagrelor in patients with history of MI and high risk of developing atherothrombotic events. Enrollment complete
LAPTOP - SUMMA Site, Akron OH. Studying new ways to manage heart failure with Implanted Left Atrial Pressure (LAP) Monitoring System
ACCELERATE – Principle Investigator at SUMMA: CETP Inhibitor for patients at high risk for vascular outcomes. Enrollment complete
1984-86nbsp; Columbia University College of Physicians and Surgeons, NYC, NY. Helped develop and validate a cinevideodensitometric analysis system for quantitating percent coronary stenoses on coronary arteriograms.
1988-94nbsp; University of Massachusetts Medical Center, Worcester, MA. 1) Studied coronary blood flow hemodynamics using a Doppler-tipped guidewire system; 2) Studied differences in cholesterol management after angioplasty in men and women; 3) Long axis shortening patterns in LVH; 4) Reactive versus passive pulmonary hypertension in aortic stenosis; 5) Myocardial hypertrophy in men and women.
1994-96 Dallas, TX, Clinical Research: 1) Losartan for congestive heart failure; 2) Dofetilide for atrial fibrillation; 3) dl-Sotalol for atrial fibrillation.
1996-99 Westwood, NJ: AFFIRM Study. Afib – rhythm control vs rate control and anticoagulation. Westwood, NJ
Completed Studies at Summa Health Systems, Akron, OH:
TRACER – Principal Investigator at SUMMA – Studying the effects of a novel thrombin receptor antagonist in NSTEMIs
CURRENT - Principal Investigator. SUMMA Site. High vs intermediate dose Clopidogrel loading in Acute Coronary Syndromes.
OAT (Open Artery Trial) – Principal Investigator at SUMMA – Studying the “open artery hypothesis.”
VALIANT Trial - Co-Investigator. SUMMA Site, Akron, OH. Valsartan and Enalapril in patients with reduced LV function.
EASE Trial - Co-Investigator. SUMMA Site, Akron, OH. Zetia for hyperlipidemia.
EASE II Trial - Co-Investigator. SUMMA Site, Akron, OH
SYNERGY Trial, Akron, OH. Principal Investigator at SUMMA.
Use of LMWH vs UFH in Unstable Angina.
ADVANCET Trial - Co-Investigator. SUMMA Site, Akron, OH. Guidant sponsored.
Registry for CHF Patients.
AMETHYST Trial - Co-Investigator. SUMMA Site, Akron, OH. Novel distal protection filter for grafts in PCI.
OASIS 5 - Co-Investigator. SUMMA Site, Akron, OH.
Use of a novel platelet inhibitor in unstable angina.
WATCHMAN Trial - Co-Investigator, SUMMA Site, Akron, OH
Left atrial appendage occluder to prevent thromboembolism in atrial fibrillation without coumadin.
ENDEAVOR IV Trial - Co-Investigator, SUMMA Site, Akron, OH
Comparing everolimus coated versus paclitaxil coated stents for de-novo coronary lesions.
PROMISE - Studying if coronary CTA will improve clinical outcomes in subjects with symptoms concerning for coronary artery disease
Puliafico SB, Penn MS, Silver KH. Stem Cell Therapy for Heart Disease Journal of General Internal Medicine 2013;10;1353-1363.
Penn MS, Silver KH. Strategies for Cardiovascular Repair: Role of Stem Cells in 2012. Minerva Cardioangiologica October 2012;60(5):451-60
McIntyre-Spatar LL, Silver KH. Spontaneous coronary artery dissection in a postpartum woman: Literature review. The Journal for Nurse Practitioners 2011;7(5):770-773.
Silver KH, Newman I, Rohr SM, Johnson J, Josephson RA. Administration of a Glycoprotein IIb/IIIa Receptor Blocker with a Thienopyridine Derivative Does Not Increase the Risk of Thrombocytopenia. Ohio J Sci 2005;4:74-78.
Rohr SM, Rich MW, Silver KH. Shortness of Breath, Syncope, and Cardiac Arrest Caused by Systemic Mastocytosis. Ann Emergency Med, 2005; 45(6):592-594.
Silver KH, Bauman WB, Berkovitz K. Dual Chamber Covered Stenting: A Novel Approach to the Treatment of Large Coronary Artery Perforations. J Invasive Cardiol 2003;15:348-350.
Aurigemma GP, Silver KH, Priest MA, Gaasch WH. Geometric Changes Allow Normal Ejection Fraction Despite Depressed Myocardial Shortening in Hypertensive Left Ventricular Hypertrophy. J Am Coll Cardiol 1995;26:195-202.
Heller LI, Silver KH, Villegas BJ, Balcom SJ, Weiner BH. Blood Flow Velocity in the Right Coronary Artery: Assessment Before and After Angioplasty. J Am Coll Cardiol 1994;24:1012-7.
Aurigemma GP, Silver KH, McLaughlin M, Mauser J, Gaasch WH. Impact of Chamber Geometry and Gender on Left Ventricular Systolic Function in Patients > 60 Years of Age with Aortic Stenosis. Am J Cardiol 1994;74:794-798.
Silver KH, Aurigemma G, Krendel S, Barry N, Ockene I, Alpert J. Pulmonary Artery Hypertension in Severe Aortic Stenosis: Incidence and Mechanism. American Heart J 1993; 125:146-150
Silver K, Alpert J. Syncope. J Intensive Care Med. 1992; 7(3): 138-148.
Aurigemma G, Davidoff A, Silver K, Boehmer J. Left Ventricular Mass Quantitation using Single Phase Cardiac Magnetic Resonance Imaging. American J Cardiol. 1992; 70: 259-262.
Silver KH, Buczek JA, Esser PD, Nichols AB. Quantitative Analysis of Coronary Arteriograms by Cinevideodensitometry. Catheterization and Cardiovascular Diagnosis. 1987; 13: 291-300.
Rohr S, Johnson J, Silver K, Josephson R, Newman I. Thrombocytopenia After Concomitant Administration of a IIb-IIIa Receptor Inhibitor and a Theinopyridine Platelet Inhibitor. Journal of General Internal Medicine 2002;17: 131.
Call DC, Silver KH, Trochelman RD, Josephson RA. Hemostatic Effects of Ticlopidine and Clopidogrel Using High Shear Stress, High Flow in vitro Analysis. Catheterization and Cardiovascular Intervention 2000; 50: 138. [Poster presentation at the Society for Cardiac Angiography and Interventions, Charleston, SC, 5/2000. PO04]
Silver KH, Heller LI, Hanna SR, Villegas BJ, Grella RD, Weiner BH. The Use Of Pacing Catheters During PTCA Of The Right Coronary Artery. [Poster presentation at
the Society for Cardiac Angiography and Interventions, Seattle, WA, 5/94]
Silver KH, Heller LI, Chung ES, Balcom SJ, Villegas BJ, Weiner BH. Changes in Coronary Blood Flow Following Angioplasty in the Left Circumflex Coronary Artery. [Poster presentation at the Society for Cardiac Angiography and Interventions, Seattle, WA, 5/94]
Silver KH, Heller LI, Borbone ML, Weiner BH. The Predictive Value of Chest Pain During PTCA. [Poster presentation at the Society for Cardiac Angiography and Interventions, Seattle, WA, 5/94]
Silver KH, Weiner BH, Borbone ML, Heller LI, Jolie MN. Serum Cholesterol Levels After Coronary Angioplasty in Men and Women. J Am Coll Cardiol 1994; 299A. [Presented at the 43rd Scientific Session of the American College of Cardiology.]
Aurigemma GP, Silver KH, Fox MA, Gaasch WH. Depressed Midwall and Long Axis Shortening in Hypertensive Left Ventricular Hypertrophy with Normal Ejection Fraction. Circulation 1993; 88(4): 2688.
Heller LI, Silver KH, Villegas BJ, Balcom SJ, Weiner BH. Changes in Coronary Blood Flow Following RCA PTCA. Circulation 1993; 88 (4): 1087.
Aurigemma GP, Silver KH, Fox MA, Gaasch WH. Left Ventricular Long Axis Shortening is Depressed in Compensated Pressure-Overload Hypertrophy. Circulation 1992; 86 (4): 2146. [Presented at the 65th Scientific Sessions of the American Heart Association, New Orleans, November, 1992.]
Aurigemma GP, Silver KH, McLaughlin M, Orsinelli D, Sweeney AM, Gaasch WH. Gender Influences the Pattern of Left Ventricular Hypertrophy in Elderly Patients with Aortic Stenosis. Circulation 1992; 86 (4): 2143.
Aurigemma GP, Davidoff A, Boehmer, Silver K. Left Ventricular Mass Quantitation in Man Using Single-Phase Cardiac MRI. J Am Coll Cardiol 1991; 17: 243A.
Silver KH, Aurigemma GP, Krendel SI, Barry N, Ockene IS, Alpert JS. Mechanism of Pulmonary Artery Hypertension in Isolated, Severe Aortic Stenosis. Circulation. 1990; 82: III-471 [Presented at the 63rd Scientific Sessions of the American Heart Association, Dallas, November, 1990.]
Silver KH, Irwin RS, Aurigemma GP. Skiagraphy in a Patient with Cheyne-Stokes Respiration. [Presented at the Massachusetts Chapter of the American College of Physicians, Sturbridge, MA, October 1989.]
Nichols AB, Silver KH, Buczek JA. Validation of a Cinevideodensitometric Microprocessor System for Measuring Coronary Stenotic Dimensions. Circulation. 1986; 74: 485.
Hollingsworth HM, Silver KH, Irwin RS, Aurigemma GP. Lethargy, Confusion, and a Mediastinal Abnormality in a 68-Year-Old Woman. Chest 1994;106:939-941.
Mascarenhas DAN, Silver KH, Heller LI, Folland ED. Intimal Invagination Due to Coronary Artery Straightening: A Temporary Iatrogenic Cause of Proximal Arterial Narrowing During Angioplasty. J Invasive Cardiol 1993; 5(8): 302-305.
Silver KH, Folland ED. Clinical Questions: Isolated Right Ventricular Failure. Choices in Cardiology. 1993;7(11): 374-377.
Silver KH, Alpert JS. Acute Right Ventricular Failure with Rapid Resolution. Primary Cardiology. 1989; 15: 15-7. (Reprinted in Physicians Assistant 11/89.)
Hendel R, Silver K, Cuenoud H, Pape L. Giant Anomalous Band: An Echocardiographic Diagnosis. American Journal of Noninvasive Cardiology. 1988; 2: 310-2.
Silver KH, Aaron C. Anticholinergic Toxicity. in Rippe JM, Irwin RS, Alpert JS, Fink MP (eds): Intensive Care Medicine, ed 2. Boston, Little, Brown and Company, 1991, pp. 1122-1126.
Silver KH, Howe JP, Rippe JM. Syncope, in Rippe JM, Irwin RS, Alpert JS, Fink MP (eds): Intensive Care Medicine, ed 2. Boston, Little, Brown and Company, 1991, pp. 348-355.