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An Institutional Review Board (IRB) reviews proposed human subjects research with the goal of protecting the rights and welfare of the subjects. The review involves ensuring that risks are minimized and that potential benefits to subjects have been maximized.  IRB’s help ensure that federal, state, and local regulations are complied with for the protection and welfare of subjects, investigators, and the institution. The IRB also ensures, when required, that human subjects only volunteer to participate in research after providing legally effective informed consent.