Skip to main content.

A Warm, Buttery Flavor — and a Risk of Irreversible Lung Damage

Posted March 31, 2025

Doctor holding a scan of lungs and a vape

After decades of prevalent tobacco warnings, the popularity of vaping has increased significantly — particularly among individuals looking for an alternative to smoking cigarettes. The attraction to vaping is often due to its variety of flavors, the belief that it is less harmful than smoking and the convenience of e-cigarettes. However, along with the rise in vaping's popularity, concerns regarding its long-term health effects have escalated. One of the most significant risks that has gained attention is the potential development of a serious respiratory disease nicknamed popcorn lung.

What is Popcorn Lung? 

Popcorn lung (bronchiolitis obliterans), is a disease that damages the tiny airways in the lungs, known as bronchioles. This condition causes the airways to become inflamed and permanently scarred, leading to reduced airflow and difficulty breathing. The term popcorn lung was coined in the early 2000s when popcorn factory workers started getting sick. The cause was traced back to exposure to a chemical called diacetyl, which was used in artificial butter flavoring. 

While popcorn lung is a rare disease, its association with vaping has raised concerns in the healthcare community. 

The Link Between Vaping and Popcorn Lung 

While it is more commonly used in food products for its buttery flavor, diacetyl has also been found in butter, cream and custard e-cigarette flavors. Although the exact amount of diacetyl in e-cigarettes varies, research suggests even low levels of exposure may pose a risk to lung health. 

Studies conducted in recent years have shown some flavored e-liquids still contain diacetyl, even though manufacturers have claimed it has been removed from their products. The presence of diacetyl in vaping products has sparked concerns, especially as vaping continues to be marketed as a safer alternative to smoking, and more young people take up the habit. 

How Does Diacetyl Affect the Lungs? 

When diacetyl is inhaled, it can lead to severe lung damage. This is particularly dangerous because it doesn’t just affect the large airways; it travels to the small airways deep within the lungs, leading to scarring and inflammation. Popcorn lung has no lasting treatment. There are supportive measures that can help manage symptoms. As the disease progresses, the lungs become less efficient at transferring oxygen to the bloodstream, leading to symptoms such as: 

  • Persistent cough 
  • Shortness of breath 
  • Wheezing 
  • Fatigue 
  • Chest pain or tightness 
  • Coughing up blood or blood-tinged mucus 
If left untreated, popcorn lung can result in irreversible lung damage, and in extreme cases, may require a lung transplant. 

The Risks of Vaping: Are You at Risk? 

While the risk of developing popcorn lung from vaping is still being studied, it’s clear certain factors can increase the chances of harm: 
  • Flavored E-Liquids: E-liquids, particularly those with buttery, creamy or custard-like flavors, may contain diacetyl or other harmful chemicals. If you’re a regular user of flavored e-cigarettes, your risk of exposure increases. 
  • Frequency of Use: The more you vape, the higher the potential for harmful chemicals to deposit in your lungs. Even e-cigarettes without diacetyl may contain other chemicals capable of causing lung damage over time. 
  • Low-Quality or Unregulated Products: Many e-liquids are produced without regulation or quality control. This can lead to inconsistencies in the ingredients, increasing the risk of exposure to harmful substances. 
  • Young Users: Teenagers and young adults are particularly vulnerable to the risks of vaping, as their lungs are still developing. Furthermore, studies suggest that nicotine exposure at an early age can have long-term effects on brain development and lung health. 

Can Popcorn Lung Be Prevented? 

The best way to prevent popcorn lung and other vaping-related illness is to avoid vaping altogether. While vaping may seem less harmful than smoking, it still carries risks, especially if the products contain harmful chemicals like diacetyl.

If you’re already vaping and concerned about the potential risks, consider the following:

  • Check the Ingredients: Look for e-liquids that are labeled as diacetyl-free. Keep in mind the long-term effects of other chemicals in e-liquids are still unknown. 
  • Limit Use: Reduce your frequency of vaping, especially with flavored e-liquids, to decrease your exposure to harmful chemicals. 
  • Consider Quitting: If you’re using vaping as a smoking cessation tool, it’s important to have a plan in place to quit altogether. There are many resources available to help transition from vaping or smoking to a healthier lifestyle. 

Secondhand Vapor Isn’t Safe Either 

It’s a myth that secondhand vapor from e-cigarettes is harmless. Many people think secondhand vapor is just water, but this couldn’t be farther from the truth. The vapor emitted when someone exhales contain a variety of dangerous substances, which may include: 

  • Nicotine 
  • Ultrafine particles 
  • Diacetyl 
  • Benzene (a chemical also found in car exhaust) 
Although secondhand vapor may not affect the lungs the same way as vaping, it is better to avoid it if possible. 

The Bottom Line 

While vaping is often seen as a safer alternative to smoking, it still creates health risks. The potential for developing popcorn lung from inhaling chemicals like diacetyl should not be taken lightly. As more research is conducted on the long-term effects of vaping, it’s important to stay informed and make choices that prioritize your health. If you’re concerned about vaping’s potential impact on your lungs, it’s always a good idea to consult a healthcare professional for advice. 

In the end, the best way to protect your lungs is to avoid exposure to harmful chemicals, whether from cigarettes, e-cigarettes or other sources. Taking steps to reduce your risk now can lead to better lung health in the future.

About the Author

Nicole Piriak BS, RRT, CTTS

Vitality eNews Sign Up

Receive the Summa Health eNewsletter for the latest health tips, advice and updates.

Related Blogs

View all Flourish Blogs

For the Right Patients, Pulse Oximeters Can Deliver a Sigh of Relief

Even without a medical degree, having certain medical equipment in the home can be a helpful way to keep an eye on your or a loved one’s health. For instance, most people are familiar with using a thermometer to determine if you are experiencing a fever. People who have or suspect they are experiencing a respiratory issue or illness may fine an at home oxygen meter just as helpful—and easy to use—as a trusty thermometer.

At home oxygen meters, more commonly…

What Are Your Lungs Capable Of Four Ways You Could Improve Your Lung Capacity

For the 2015 film, “Mission Impossible: Rogue Nation”, Tom Cruise held his breath for approximately six minutes while filming an underwater stunt. Kate Winslet broke Cruise’s record during the production of the 2022 film, “Avatar: The Way of Water”, when she held her breath underwater for an astonishing seven minutes and 15 seconds. While these feats of lung power are far beyond normal pulmonary expectations, they are great examples that with the…

Have a Cough that Just Won’t Go Away? What You Should Know About Chronic Cough and Its Causes

While chronic cough is sometimes a symptom, but sometimes it’s also its own disease and a distinct clinical entity that requires careful diagnosis and close attention. Chronic cough is a common problem, affecting nearly 10 percent of the population. There are geographical, genetic and environmental factors which may contribute to a patient having chronic cough. 

Here at Summa Health, a team of professionals are prepared to help you with advanced tools, tests and…

What Type of COPD Do I Have and How is it Treated?

If you have been recently diagnosed with Chronic obstructive pulmonary disease (COPD) its important to understand that COPD isn’t just one disease, it’s a spectrum of conditions that impacts the ability to get air out of the lungs. COPD is a common condition that can be treated more successfully when you know what type of COPD you have been diagnosed with and how to manage it. 

COPD claims nearly as many lives as some cancers and due to the various causes and…

A Partner in Health: How Patient Navigators Empower and Support Patients

Imagine navigating a health system during a stressful time, like a new diagnosis or chronic illness. That’s where patient navigators come in—they act as personal guides to help patients receive the best possible care at Summa Health. 

Patient navigators bridge the gap between our patients and the medical system. Although their backgrounds vary, they all deeply understand the healthcare landscape and are passionate about patient advocacy.

Patient navigators…

Addressing Myths of Quitting Tobacco

Quitting tobacco is hard – let’s start with that. It is not easy to quit. There is a lot of information out there describing the health benefits of quitting tobacco. For instance, the sooner you quit tobacco, the more you can reduce your risk of: 
  • Heart disease 
  • Stroke 
  • Respiratory conditions 
  • Various cancers 
The health risks of using tobacco are widely known, and yet, people still use it. Even for those who want to quit, it is estimated…

Lung Cancer Screening and the Advancements in Lung Cancer Detection and Treatment [Podcast]

Dr. Aziken, a cardiothoracic surgeon at Summa Health, reviews the importance of lung cancer screenings, who is at risk of developing lung cancer, some of advancements in the treatment of lung cancer and debunks common myths.

Incorporate These 5 Daily Habits to Improve Your Lung Health

Prioritizing your lung health is very important, especially if you’re suffering from chronic lung conditions, such as COPD (chronic obstructive pulmonary disease), lung cancer or asthma.

Your lungs allow you to take in oxygen from the air you breathe and are the key to carrying it to all your organ systems to keep them running efficiently, while clearing your body of carbon dioxide.

The body has a natural defense system designed to protect the lungs, and help keep dirt…

Lung Cancer Patients Are Living Longer. Find Out Why

Lung cancer is the second most commonly diagnosed cancer in both males and females in the United States, and according to the American Cancer Society (ACS), is the leading cause of cancer deaths, making up almost 25% of cases.

While smoking is the leading cause of lung cancer, nonsmokers can be diagnosed with cancer as well. Exposure to radon, asbestos, and secondhand smoke are some of the other risk factors that can increase your risk of developing lung cancer.

The good news…

'Tis the season to avoid asthma triggers

Updated November 2024

You know winter has arrived when the days get shorter, snow flurries fill the air and you can see your breath when you speak. When temperatures hover around freezing for months on end, it can make for a long and dreary season for many.

But for people with asthma, it can be even more frightful when the frigid winter weather causes their symptoms to worsen. Exposure to cold, dry air is a common asthma trigger and can quickly cause severe symptoms.

When cold,…

All About COPD [Podcast]

Healthy VitalsListen to this episode of the Healthy Vitals Podcast featuring Paul Bailey, a registered respiratory therapist, and Sarah Serb, an acute nurse practitioner.

Living with COPD? What you need to know

Smoking cigarettes is a dangerous habit that damages nearly every organ in the body, leading to disease and long-term disability.

People who smoke are at a higher risk for lung cancer, stroke, heart disease, diabetes, tuberculosis, eye diseases, and the list goes on. Another major health effect caused from smoking is chronic obstructive pulmonary disease or COPD.

COPD is a lung disease that affects the way air flows in and out of your lungs, making it difficult to breathe.…

Respiratory Therapists: Who they are and what they treat

Are you suffering from asthma, bronchitis, emphysema or another lung problem? A respiratory therapist may be able to help.

One out of six Americans will suffer from a serious pulmonary (lung) disease at some time in their lives. Of those afflicted, however, many patients don’t realize a respiratory therapist can help them overcome breathing problems and breathe easier — all the while increasing their quality of life.

As vital members of the healthcare team,…

Are you high-risk? Lung health and lower respiratory disease

Chronic lower respiratory disease is the third leading cause of death, behind cancer and heart disease in Ohio. Chronic lower respiratory disease is a broad term that includes a variety of diseases that affect the lungs, like: chronic obstructive pulmonary disease (COPD), emphysema (a type of COPD), chronic bronchitis and non-reversible asthma.

Roughly one in six Americans will suffer from some pulmonary disease in their lifetime. Most of those affected usually associate…

What is a Lung Nodule?

Lung nodules are abnormal clusters of tissue that appear as “spots” on chest X-rays and CT scans. All lung cancers starts as a nodule; however, these spots are very common and almost 95 percent of them are not cancerous.

Lung cancer is a very tragic disease. It has the lowest 5-year survival rate of all cancers and leads to more deaths that the next 3 deadliest cancers (colorectal, pancreatic and breast) combined.
Most lung cancers are not diagnosed and treated at an early stage, contributing to the low survival rate. However, early detection, by low-dose CT screening, can increase that rate by up to 20 percent in high-risk patients.

[{"RootId":"ba198066-3078-4dcd-8e69-28251bebb940","RootUrl":"/glossary/"}]

Options to Request an Appointment

If your situation is an emergency, call 911.